Agmatine Sulfate
Also known as: agmatine, decarboxylated arginine, 4-(aminobutyl)guanidine sulfate
A metabolite of arginine that acts as a neuromodulator, binding imidazoline and NMDA receptors and influencing nitric-oxide synthase. It is used in pump, mood, and nootropic products, but nearly all supporting data come from animals; the human literature is limited to small trials and a long-term single-subject safety report. Its status as a lawful dietary ingredient in the US has been questioned, so sourcing and regulatory review are advisable.
Research summary
Modulates NMDA and imidazoline receptors and inhibits inducible nitric-oxide synthase; proposed to enhance nitric-oxide signaling in muscle.
Dosage
Daily amounts, of compound.
| Lowest studied | Typical range | Highest studied | Upper limit |
|---|---|---|---|
| — | 500–1,500 mg | 2,670 mg | — |
Products use 500–1,500 mg per serving. Human studies used 1.3–3.6 g/day for lumbar pain, and one long-term case report documented 2.67 g/day for five years without adverse findings. No performance dose has been established.
Source material: synthetic
Format suitability
- Capsule
- Powder
- Tablet
- Softgel
- Gummy
- Liquid
Soluble with a mildly bitter, salty taste; suits pre-workout powders and capsules.
Formulation notes
Often paired with citrulline and arginine in pump formulas. Possible additive effects with blood-pressure or blood-sugar medications are a label consideration.
- NDI status uncertain
Sources
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