Cissus Quadrangularis Extract
Also known as: Cissus quadrangularis, veldt grape, hadjod, adamant creeper, CQR-300
Cissus quadrangularis is a succulent vine used in Ayurveda for bone and joint recovery, where it is known as hadjod, the bone setter. It contains ketosteroids, flavonoids, and triterpenoids. A meta-analysis of nine RCTs found benefit on bone-related pain, and an 8-week open-label pilot of 3,200 mg per day reduced joint discomfort in exercise-trained men. It is used in joint, bone, and weight-management formulas at 500–1,500 mg of extract per day.
Research summary
Ketosteroids and flavonoids are proposed to support osteoblast activity and modulate inflammatory signaling.
Dosage
Daily amounts, of extract.
| Lowest studied | Typical range | Highest studied | Upper limit |
|---|---|---|---|
| — | 500–1,500 mg | 3,200 mg | — |
500–1,500 mg of extract per day in divided doses with food; the joint-pain pilot used 3,200 mg daily for 8 weeks without clinical-marker changes. Trials used various extracts (aqueous, ethanolic, and the CQR-300 branded extract), so standardization is not uniform.
Standardization: often 2.5% ketosteroids; some grades sold as 10:1 or 20:1 extracts
Source material: stem extract
Format suitability
- Capsule
- Powder
- Tablet
- Softgel
- Gummy
- Liquid
Tan powder with a bland, slightly sour taste; capsules and tablets standard. Gram-level doses raise capsule counts.
Formulation notes
No notable formulation conflicts. Limited safety data in pregnancy.
Sources
Related ingredients
Magnesium Glycinate
MineralA chelated form of magnesium bound to the amino acid glycine.
Typical: 200–350 mg
Collagen Peptides (Bovine, Type I/III)
ProteinEnzymatically hydrolyzed collagen from bovine hide or bone, delivering short peptides rich in glycine, proline, and hydroxyproline.
Typical: 2.5–15 g
Magnesium Citrate
MineralMagnesium bound to citric acid, one of the best-selling magnesium forms because it is inexpensive, dissolves readily, and has shown good bioavailability in comparison studies.
Typical: 150–350 mg
MSM (Methylsulfonylmethane)
OtherMSM is an organic sulfur compound found in small amounts in plants, milk, and the body.
Typical: 1,500–3,000 mg
Curcumin Phytosome (Meriva)
BotanicalA branded curcumin delivery form in which curcuminoids are complexed with sunflower lecithin (a phytosome) to improve uptake.
Typical: 500–1,000 mg