Passionflower Extract

BotanicalcalmingModerate dose evidence

Also known as: Passiflora incarnata, maypop, passion flower, passiflora extract

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An extract of the aerial parts of Passiflora incarnata, a climbing vine used in calming and sleep formulas. A double-blind trial found that a single 500 mg oral dose taken before ambulatory surgery reduced pre-procedure anxiety without slowing recovery, and an earlier four-week pilot compared a liquid extract favorably with a benzodiazepine on anxiety scores. It is mild, pairs well with valerian and lemon balm, and is usually taken in the evening.

Research summary

Flavonoids such as vitexin and chrysin, along with harman alkaloids, are proposed to modulate GABA-A receptor activity and reduce central excitability.

Dosage

Daily amounts, of extract.

Lowest studiedTypical rangeHighest studiedUpper limit
250–500 mg500 mg

250 to 500 mg per day of extract, taken in the evening or 60 to 90 minutes before a stressful event. The oral capsule trial used a single 500 mg dose. Mild drowsiness is possible, so daytime use is best at the low end.

Standardization: 3.5–4% flavonoids (as vitexin)

Source material: aerial parts extract

Format suitability

  • Capsule
  • Powder
  • Tablet
  • Softgel
  • Gummy
  • Liquid

Mild, grassy flavor; workable in gummies and liquids.

Formulation notes

Additive sedation with valerian, hops, and other calming ingredients. Commonly combined with lemon balm and magnesium.

  • Not for pregnancy

Sources

  1. Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study. (Movafegh 2008)PubMed
  2. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. (Akhondzadeh 2001)PubMed

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