Pueraria Mirifica Root Extract (Pueraria candollei var. mirifica)
Also known as: Pueraria candollei var. mirifica, Thai Kudzu, White Kwao Krua, Kwao Krua
Pueraria mirifica, also known as White Kwao Krua, is a plant native to Thailand. Its tuberous root has a long history of use in traditional Thai medicine. Modern dietary supplements use extracts of the root, which is a rich source of phytoestrogens, including isoflavonoids (e.g., puerarin) and unique chromenes like miroestrol and deoxymiroestrol. Human clinical studies have investigated Pueraria mirifica extract for its potential to support women's health during and after menopause, particularly in relation to vasomotor symptoms (hot flashes) and vaginal health.
Research summary
The active compounds in Pueraria mirifica, particularly miroestrol and deoxymiroestrol, are potent phytoestrogens that bind to estrogen receptors, which may help support the body's response to declining estrogen levels.
Dosage
Daily amounts, of extract.
| Lowest studied | Typical range | Highest studied | Upper limit |
|---|---|---|---|
| 25 mg | 50–100 mg | 100 mg | — |
Doses are typically taken as an encapsulated extract once daily. Clinical studies investigating support for menopausal symptoms have used doses ranging from 25 mg to 100 mg per day for periods of up to 12 months.
Standardization: Standardized to contain specific phytoestrogens, such as miroestrol and deoxymiroestrol, or a total isoflavonoid content.
Source material: Tuberous root of Pueraria candollei var. mirifica
Format suitability
- Capsule
- Powder
- Tablet
- Softgel
- Gummy
- Liquid
The powder extract is most commonly supplied in capsules and tablets. It is also formulated into topical creams and gels for cosmetic applications, though this record pertains to oral supplements.
Formulation notes
Due to its potent phytoestrogenic activity, Pueraria mirifica may interact with hormone replacement therapy (HRT), oral contraceptives, and other hormone-modulating medications. It should be used with caution by individuals with a history of hormone-sensitive conditions.
- Not for pregnancy
- Notable drug interactions
- NDI status uncertain
Sources
Related ingredients
Collagen Peptides (Bovine, Type I/III)
ProteinEnzymatically hydrolyzed collagen from bovine hide or bone, delivering short peptides rich in glycine, proline, and hydroxyproline.
Typical: 2.5–15 g
Maca Root Powder
BotanicalA cruciferous root grown in the Peruvian Andes, dried and milled into a powder used in libido, energy, and hormone-balance formulas.
Typical: 1,500–3,000 mg
Boron (Citrate/Glycinate Complex)
MineralBoron supplied as a blend of citrate, aspartate, and glycinate complexes, the usual form in bone, joint, and men's-hormone formulas.
Typical: 3–10 mg
Horny Goat Weed (Epimedium)
BotanicalHorny goat weed is the common name for several Epimedium species used in traditional Chinese herbalism.
Typical: 500–1,000 mg
Evening Primrose Oil
Fatty acidEvening primrose oil is pressed from the seeds of Oenothera biennis and is valued for its gamma-linolenic acid (GLA), an omega-6 fatty acid that usually makes up 8-10% of the oil, with linoleic acid as the bulk.
Typical: 500–1,300 mg