Potassium Chloride

MineralStrong dose evidence

Also known as: KCl, potassium chloride USP, salt substitute potassium

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The most concentrated common potassium source at about 52% elemental potassium, and the salt used in most blood-pressure trials of potassium supplementation. It is the backbone of electrolyte powders and salt substitutes, with a sharp salty-bitter taste that needs masking. Solid-dose supplements in the US are commonly limited to 99 mg per unit because higher-dose potassium chloride tablets have been linked to small-bowel irritation, so larger amounts are typically delivered as powder or liquid.

Research summary

Supplies potassium and chloride ions for membrane potential, nerve conduction, muscle contraction, and fluid balance; higher potassium intake supports sodium excretion.

Dosage

Daily amounts, elemental (52% of the compound is the element).

Lowest studiedTypical rangeHighest studiedUpper limit
99 mg99–500 mg4,692 mg

Doses are elemental potassium. Supplement makers commonly keep solid-dose products to 99 mg per capsule or tablet, so 99 mg is the practical floor and ceiling for tablets while electrolyte powders often deliver 200–500 mg per serving. Blood-pressure trials used 30–120 mmol/day (about 1,173–4,692 mg) mostly as potassium chloride, taken with meals and fluid. No UL is set; the adult AI is 2,600–3,400 mg/day. Take with a full glass of water to limit gastric irritation. Potassium chloride (MW 74.55) is 52.4% K.

Source material: mined sylvite or brine, refined to USP/FCC grade

As supplied: ≈ 52% K; 500 mg elemental ≈ 960 mg compound

Forms of Potassium

FormTypical doseElement %FormatsPrice
Potassium Chloride99–500 mg52%Capsule, Powder, Tablet, Liquidlow
Potassium Citrate99–500 mg36%Capsule, Powder, Tablet, Gummy, Liquidlow
Potassium Gluconate99–300 mg17%Capsule, Powder, Tablet, Liquidlow

Format suitability

  • Capsule
  • Powder
  • Tablet
  • Softgel
  • Gummy
  • Liquid

Most solid-dose products in the US hold potassium to 99 mg per capsule or tablet by industry convention, so meaningful amounts are usually delivered as powders or liquids. Strong metallic bitterness; usually blended with citrate or masked with citric acid and flavor. Hygroscopic.

Formulation notes

Potassium raises serum levels further in people taking ACE inhibitors, angiotensin receptor blockers, or potassium-sparing diuretics, and in kidney disease; formulations above the 99 mg convention commonly carry an advisory. Pairs with sodium, magnesium, and chloride in electrolyte blends.

  • Notable drug interactions

Sources

  1. Potassium — Health Professional Fact SheetNIH ODS
  2. Potassium Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled Trials (Filippini 2020)PubMed
  3. Dietary Reference Intakes for Sodium and Potassium (NASEM 2019)Reference

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