Methylliberine (Dynamine)
Also known as: Dynamine, methylliberine, 2-methoxy-1,7,9-tetramethyluric acid, kucha methylliberine
Methylliberine is a purine alkaloid found in kucha tea leaves and coffee, structurally close to theacrine but with a faster onset and shorter duration. Branded as Dynamine, it is marketed for quick energy, mood, and focus in pre-workouts and gaming supplements, typically stacked with caffeine and theacrine. A 4-week RCT at 100 and 150 mg per day, alone and with theacrine, found no clinically meaningful changes in cardiovascular or blood safety markers; a later trial reported improved affect but not cognition.
Research summary
Adenosine receptor antagonist and dopaminergic purine alkaloid with rapid absorption and a shorter half-life than theacrine.
Dosage
Daily amounts, of compound.
| Lowest studied | Typical range | Highest studied | Upper limit |
|---|---|---|---|
| 100 mg | 100–150 mg | 150 mg | — |
100–150 mg per day, typically with 25–50 mg theacrine and caffeine. Onset is fast (within 30 minutes) and duration shorter than theacrine, which is why it is paired. Four-week safety data exist at these doses; longer-term data are limited.
Standardization: ≥40% methylliberine (Dynamine 40%) or ≥99% pure grade
Source material: synthetic, nature-identical (branded Dynamine)
As supplied: Dynamine is commonly supplied as a 40% grade; 100 mg methylliberine requires 250 mg of 40% material. A 100% grade also exists.
Format suitability
- Capsule
- Powder
- Tablet
- Softgel
- Gummy
- Liquid
Bitter; flavored powders, capsules, and tablets are standard.
Formulation notes
Stimulant; additive with caffeine and theacrine. Avoid with other stimulants and in stimulant-sensitive users.
- Stimulant
Sources
- Safety of Short-Term Supplementation with Methylliberine (Dynamine(®)) Alone and in Combination with TeaCrine(®) in Young Adults. (VanDusseldorp, 2020)PubMed
- Methylliberine Ingestion Improves Various Indices of Affect but Not Cognitive Function in Healthy Men and Women. (La Monica, 2023)PubMed
- Compound Solutions — DynamineSupplier
Related ingredients
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Acetyl-L-Carnitine
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Typical: 500–2,000 mg
Theacrine (TeaCrine)
Sports performanceTheacrine is a purine alkaloid structurally related to caffeine, found in kucha tea and cupuaçu.
Typical: 50–200 mg
Caffeine Anhydrous
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Typical: 100–200 mg
L-Theanine
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Typical: 100–200 mg