Best ingredients for energy
Physical and mental energy, fatigue resistance. These ingredients are studied for or commonly used for energy. Doses on each page come from NIH guidance and published research.
Caffeine Anhydrous
Sports performancePurified, dehydrated caffeine — the standard stimulant in pre-workouts, energy, and focus products.
Typical: 100–200 mg
CoQ10 (Ubiquinone)
AntioxidantCoenzyme Q10 in its oxidized form, ubiquinone, is the standard, most-studied CoQ10 ingredient.
Typical: 100–300 mg
Vitamin B12 (Cyanocobalamin)
VitaminCyanocobalamin is the synthetic, highly stable form of vitamin B12 used in most supplements and fortified foods.
Typical: 100–1,000 mcg
Green Tea Extract (50% EGCG)
BotanicalA leaf extract of Camellia sinensis concentrated for catechins, especially EGCG, with a small amount of naturally occurring caffeine.
Typical: 300–500 mg
Vitamin B12 (Methylcobalamin)
VitaminMethylcobalamin is one of the two coenzyme forms of vitamin B12 that the body uses directly, in this case for the methionine synthase reaction that recycles homocysteine and supports methylation.
Typical: 100–1,000 mcg
Beet Root Powder
BotanicalDried and milled beet root or beet juice, used in pre-workout, endurance, and heart-health powders as a whole-food source of dietary nitrate.
Typical: 5–10 g
Iron Bisglycinate
MineralFerrous iron chelated with two glycine molecules, the form most prenatal and gentle-iron products now use.
Typical: 18–30 mg
MCT Oil
Fatty acidMCT oil is a clear, flavorless oil made by fractionating coconut or palm kernel oil to isolate the medium-chain fatty acids caprylic (C8) and capric (C10) acid as triglycerides.
Typical: 5–15 g
L-Tyrosine
Amino acidA conditionally essential amino acid that serves as the direct precursor to dopamine, norepinephrine, and epinephrine.
Typical: 500–2,000 mg
Alpha-Lipoic Acid (racemic)
AntioxidantAlpha-lipoic acid is a sulfur-containing compound that serves as a mitochondrial enzyme cofactor and a water- and fat-soluble antioxidant.
Typical: 300–600 mg
Rhodiola Rosea Extract
BotanicalA root extract from an arctic and alpine plant, standardized to rosavins and salidroside, that is used in energy, focus, and stress formulas.
Typical: 200–600 mg
Maca Root Powder
BotanicalA cruciferous root grown in the Peruvian Andes, dried and milled into a powder used in libido, energy, and hormone-balance formulas.
Typical: 1,500–3,000 mg
Vitamin B6 (Pyridoxine HCl)
VitaminPyridoxine hydrochloride is the standard, inexpensive, and highly stable form of vitamin B6 used in nearly all multivitamins and B-complex products.
Typical: 1.7–50 mg
Iron (Ferrous Sulfate)
MineralThe reference iron salt used in most clinical research and public-health programs, inexpensive and reliably absorbed.
Typical: 18–45 mg
Maltodextrin
OtherMaltodextrin is a partially hydrolyzed starch consisting of short glucose chains, characterized by a dextrose-equivalent (DE) value that indicates how far the starch has been broken down.
Typical: 15–30 g
Panax Ginseng Extract
BotanicalThe root of Asian ginseng, standardized to ginsenosides, used in energy, fatigue, and vitality products.
Typical: 200–400 mg
Potassium Iodide
MineralThe standard iodine source in multivitamins, prenatals, and thyroid-support formulas, about 76.5% iodine by weight and absorbed almost completely.
Typical: 150–300 mcg
Acetyl-L-Carnitine
Amino acidAn acetylated form of carnitine that crosses the blood-brain barrier more readily than carnitine itself and donates acetyl groups for acetylcholine synthesis.
Typical: 500–2,000 mg
Niacinamide (Nicotinamide)
VitaminNiacinamide is the amide form of vitamin B3 and the niacin source used in most multivitamins because it delivers full NAD-precursor activity without the skin flush of nicotinic acid.
Typical: 16–35 mg
CoQ10 (Ubiquinol)
AntioxidantUbiquinol is the reduced, active antioxidant form of coenzyme Q10 and the form that predominates in blood.
Typical: 100–200 mg
Cordyceps militaris
MushroomCordyceps militaris is the cultivated, fruiting-body species that has replaced wild Cordyceps sinensis in most supplements because it grows on grain or liquid substrate at scale and contains measurable cordycepin.
Typical: 1,000–3,000 mg
L-Carnitine L-Tartrate
Amino acidA stable, highly soluble salt of L-carnitine with tartaric acid, the form most used in exercise-recovery research.
Typical: 1,000–2,000 mg
Guarana Extract
BotanicalGuarana is the seed of Paullinia cupana, an Amazonian vine whose seeds contain more caffeine by weight than coffee beans, along with theobromine and tannins.
Typical: 100–400 mg
Tongkat Ali Root Extract
BotanicalA root extract from a Southeast Asian shrub used in men's vitality, stress, and libido formulas.
Typical: 200–400 mg
MCT Oil Powder
Fatty acidMCT oil powder is MCT oil spray-dried onto a carbohydrate carrier, most often acacia gum or maltodextrin, to produce a free-flowing powder that disperses in water.
Typical: 5–10 g
Thiamin HCl (Vitamin B1)
VitaminThiamin hydrochloride is one of the two standard water-soluble salts of vitamin B1 used in supplements (the other is the mononitrate).
Typical: 1.5–100 mg
Dextrose
OtherDextrose is crystalline D-glucose, usually produced by hydrolyzing corn starch.
Typical: 10–30 g
Magnesium Malate
MineralMagnesium paired with malic acid, an intermediate of the Krebs cycle.
Typical: 100–350 mg
Niacin (Nicotinic Acid)
VitaminNicotinic acid is the acid form of vitamin B3 and, with nicotinamide, one of the two standard niacin sources in supplements.
Typical: 16–35 mg
Riboflavin (Vitamin B2)
VitaminRiboflavin is the yellow, water-soluble B vitamin that the body builds into the flavin coenzymes FMN and FAD, which drive energy production and the recycling of other vitamins including B6, folate, and niacin.
Typical: 1.3–400 mg
Cluster Dextrin (Highly Branched Cyclic Dextrin)
OtherHighly branched cyclic dextrin (HBCD) is a glucose polymer made by acting on amylopectin with a branching enzyme, producing large cyclic molecules with a narrow molecular-weight distribution.
Typical: 15–30 g
Iron (Ferrous Fumarate)
MineralA ferrous salt of fumaric acid that carries about 33% elemental iron, the highest of the common iron forms, which keeps tablets small.
Typical: 18–45 mg
Kelp (Iodine)
MineralBrown seaweed, usually Laminaria or Ascophyllum species, used as a whole-food iodine source in thyroid and multimineral formulas.
Typical: 150–300 mcg
Shilajit (Purified)
BotanicalShilajit is a blackish resin that seeps from Himalayan and other mountain rocks, formed from centuries of compressed plant matter.
Typical: 250–500 mg
Bitter Orange Extract
BotanicalBitter orange extract is made from the immature fruit or peel of Citrus aurantium and is standardized to p-synephrine, a protoalkaloid structurally related to ephedrine but with much weaker cardiovascular activity.
Typical: 200–500 mg
Theacrine (TeaCrine)
Sports performanceTheacrine is a purine alkaloid structurally related to caffeine, found in kucha tea and cupuaçu.
Typical: 50–200 mg
Pantothenic Acid (Calcium Pantothenate)
VitaminCalcium pantothenate is the stable calcium salt used to deliver pantothenic acid (vitamin B5), the building block of coenzyme A and therefore of fat, carbohydrate, and protein metabolism.
Typical: 10–500 mg
American Ginseng Extract
BotanicalThe root of a ginseng species native to North America, used in focus and calm-energy formulas.
Typical: 200–400 mg
Capsimax (Capsicum Extract)
BotanicalCapsimax is a branded red pepper extract from OmniActive standardized to 2% capsaicinoids and coated in a beadlet designed to release in the intestine rather than the stomach, limiting the burning sensation of plain cayenne.
Typical: 100 mg
Cordyceps CS-4 (Cordyceps sinensis mycelium)
MushroomCS-4 is a strain of mycelium originally isolated from wild Cordyceps sinensis and grown by liquid fermentation, which makes it far cheaper and more consistent than the wild caterpillar fungus.
Typical: 1,000–3,000 mg
Eleuthero Root Extract
BotanicalA shrub root from Siberia and northern Asia, marketed for decades as Siberian ginseng even though it is not a true Panax species.
Typical: 300–1,200 mg
Nicotinamide Riboside (NR)
VitaminNicotinamide riboside is a naturally occurring form of vitamin B3 that the body converts to NAD+ through a shorter route than niacin or niacinamide.
Typical: 250–500 mg
R-Alpha-Lipoic Acid (Na-R-ALA)
AntioxidantR-alpha-lipoic acid is the naturally occurring enantiomer of lipoic acid, the form made in mitochondria and used as a cofactor for energy-producing enzymes.
Typical: 100–300 mg
Yerba Mate Extract
BotanicalYerba mate is the leaf of Ilex paraguariensis, brewed as a tea across South America.
Typical: 500–1,500 mg
Astragalus Root Extract
BotanicalThe root of a legume used for centuries in Chinese herbal practice as a tonic, now included in immune, energy, and longevity formulas.
Typical: 250–1,000 mg
NMN (Nicotinamide Mononucleotide)
VitaminNicotinamide mononucleotide is the phosphorylated intermediate between nicotinamide riboside and NAD+ and one of the most popular healthy-aging ingredients.
Typical: 250–600 mg
PQQ (Pyrroloquinoline Quinone)
AntioxidantPyrroloquinoline quinone is a redox cofactor found in trace amounts in foods such as natto, kiwi, and green tea.
Typical: 10–20 mg
Pyridoxal 5'-Phosphate (P5P)
VitaminPyridoxal 5'-phosphate is the active coenzyme form of vitamin B6 and the form measured in blood to assess B6 status.
Typical: 1.7–50 mg
Methylliberine (Dynamine)
Sports performanceMethylliberine is a purine alkaloid found in kucha tea leaves and coffee, structurally close to theacrine but with a faster onset and shorter duration.
Typical: 100–150 mg
Schisandra Berry Extract
BotanicalAn extract of the berries of a woody vine native to northern China and Korea, prized in traditional practice as a five-flavor tonic and used in modern adaptogen, liver, and endurance formulas.
Typical: 500–1,000 mg
Palatinose (Isomaltulose)
OtherIsomaltulose is a disaccharide of glucose and fructose joined by an alpha-1,6 bond, produced enzymatically from sucrose.
Typical: 15–30 g
Benfotiamine
VitaminBenfotiamine is a synthetic, lipid-soluble derivative of thiamin that is converted to thiamin in the body.
Typical: 150–600 mg
Grains of Paradise
BotanicalGrains of paradise are the seeds of Aframomum melegueta, a West African plant in the ginger family.
Typical: 30–40 mg
Riboflavin 5'-Phosphate (FMN)
VitaminRiboflavin 5'-phosphate is the phosphorylated coenzyme form of vitamin B2 (flavin mononucleotide), supplied as its sodium salt.
Typical: 1.3–25 mg
Vitamin B12 (Adenosylcobalamin)
VitaminAdenosylcobalamin is the mitochondrial coenzyme form of vitamin B12, required by methylmalonyl-CoA mutase to feed odd-chain fatty acids and certain amino acids into the citric acid cycle.
Typical: 100–1,000 mcg