Guarana Extract

BotanicalstimulantModerate dose evidence

Also known as: Paullinia cupana, guaraná, guarana seed extract

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Guarana is the seed of Paullinia cupana, an Amazonian vine whose seeds contain more caffeine by weight than coffee beans, along with theobromine and tannins. Extracts are commonly standardized to 22% caffeine, so 100 mg of extract supplies about 22 mg of caffeine. It is a fixture in energy drinks, pre-workouts, and weight-management formulas. A systematic review and meta-analysis has examined its effects on cognitive performance, where results are partly attributable to caffeine.

Research summary

Caffeine and related methylxanthines block adenosine receptors; tannins slow caffeine release.

Dosage

Daily amounts, of extract.

Lowest studiedTypical rangeHighest studiedUpper limit
100 mg100–400 mg

Count guarana's caffeine toward total caffeine: 400 mg of a 22% extract delivers about 88 mg caffeine. Take earlier in the day. Avoid stacking with other caffeine sources without totaling.

Standardization: 22% caffeine (grades from 10% to 50% exist)

Source material: seed extract

Format suitability

  • Capsule
  • Powder
  • Tablet
  • Softgel
  • Gummy
  • Liquid

Bitter and astringent; caffeine content must be declared on the label in some jurisdictions.

Formulation notes

Stimulant; additive with caffeine anhydrous, yerba mate, green tea, and bitter orange.

  • Stimulant
  • Contains caffeine

Sources

  1. Effect of Guarana (Paullinia cupana) on Cognitive Performance: A Systematic Review and Meta-Analysis. (Hack B 2023)PubMed

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