Hesperidin
Also known as: hesperetin-7-rutinoside, citrus bioflavonoid, hesperidin methyl chalcone (related)
Hesperidin is the main flavanone glycoside of orange peel and is the principal component of most citrus bioflavonoid complexes. It is used in cardiovascular, vein, and antioxidant formulas and is frequently combined with diosmin or rutin. Trials in adults have mainly used 500 mg per day as isolated hesperidin. Like rutin, it is released as its aglycone hesperetin by gut bacteria before absorption, and glucosyl-hesperidin is a more soluble modified form.
Research summary
Studied for effects on endothelial function, blood pressure, and inflammatory markers.
Dosage
Daily amounts, of compound.
| Lowest studied | Typical range | Highest studied | Upper limit |
|---|---|---|---|
| 500 mg | 500 mg | — | — |
500 mg once daily with a meal is the dose used in most randomized trials. Onset of measurable vascular effects in studies was several weeks.
Standardization: ≥90% hesperidin
Source material: citrus peel extract
Format suitability
- Capsule
- Powder
- Tablet
- Softgel
- Gummy
- Liquid
Poorly soluble, pale powder; fine in capsules and tablets.
Formulation notes
Commonly paired with diosmin, rutin, and vitamin C.
Sources
Related ingredients
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Typical: 100–300 mg
Green Tea Extract (50% EGCG)
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Vitamin E (d-Alpha-Tocopheryl Succinate)
VitaminThe succinate ester of natural (RRR or d-) alpha-tocopherol, the one vitamin E form the body maintains in plasma and the form on which the RDA is based.
Typical: 67–268 mg
Trans-Resveratrol
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Typical: 150–500 mg
CoQ10 (Ubiquinol)
AntioxidantUbiquinol is the reduced, active antioxidant form of coenzyme Q10 and the form that predominates in blood.
Typical: 100–200 mg