Trans-Resveratrol
Also known as: resveratrol, 3,5,4'-trihydroxystilbene, Polygonum cuspidatum extract, Japanese knotweed extract
Trans-resveratrol is a stilbene polyphenol found in grape skin, red wine, and, in far higher concentration, Japanese knotweed root, which is the usual commercial source. Only the trans isomer is considered active, so purity is stated as percent trans-resveratrol. It is one of the most widely used longevity and cardiovascular ingredients and is commonly combined with NMN, quercetin, or fisetin. Oral bioavailability is limited by rapid conjugation in the gut and liver.
Research summary
Studied for activation of sirtuin and AMPK pathways and for antioxidant and endothelial effects.
Dosage
Daily amounts, of compound.
| Lowest studied | Typical range | Highest studied | Upper limit |
|---|---|---|---|
| 150 mg | 150–500 mg | — | — |
Take with a fat-containing meal to improve absorption. Many trials used 150 to 500 mg once daily; higher doses appear in the literature but are less common in retail products.
Standardization: ≥98% trans-resveratrol (knotweed-derived); micronized grades available
Source material: Polygonum cuspidatum root extract or synthetic
Format suitability
- Capsule
- Powder
- Tablet
- Softgel
- Gummy
- Liquid
Light-sensitive; protect from UV. Bitter in powders.
Formulation notes
Frequently paired with quercetin or piperine to slow metabolic clearance.
Sources
Related ingredients
CoQ10 (Ubiquinone)
AntioxidantCoenzyme Q10 in its oxidized form, ubiquinone, is the standard, most-studied CoQ10 ingredient.
Typical: 100–300 mg
CoQ10 (Ubiquinol)
AntioxidantUbiquinol is the reduced, active antioxidant form of coenzyme Q10 and the form that predominates in blood.
Typical: 100–200 mg
Quercetin Dihydrate
AntioxidantQuercetin dihydrate is the standard crystalline form of the flavonol quercetin, typically extracted from Sophora japonica flower buds and supplied at 95% or higher purity.
Typical: 500–1,000 mg
Pterostilbene
AntioxidantPterostilbene is a methylated analog of resveratrol found in blueberries and Pterocarpus wood.
Typical: 50–250 mg
Tocotrienols
VitaminTocotrienols are the four unsaturated members of the vitamin E family (alpha, beta, gamma, delta), distinguished from tocopherols by a three-double-bond side chain that lets them move through membranes more freely.