Best ingredients for antioxidant
Oxidative stress defense. These ingredients are studied for or commonly used for antioxidant. Doses on each page come from NIH guidance and published research.
Vitamin C (Ascorbic Acid)
VitaminAscorbic acid is the reference form of vitamin C and the most common form in supplements; NIH ODS notes its bioavailability equals that of vitamin C naturally present in food.
Typical: 250–1,000 mg
Melatonin
OtherMelatonin is the hormone the pineal gland releases in darkness to signal night to the body clock.
Typical: 0.5–3 mg
CoQ10 (Ubiquinone)
AntioxidantCoenzyme Q10 in its oxidized form, ubiquinone, is the standard, most-studied CoQ10 ingredient.
Typical: 100–300 mg
Curcumin Extract (95% Curcuminoids)
BotanicalA concentrated turmeric rhizome extract standardized to 95% curcuminoids, the form used in most joint and inflammation research.
Typical: 500–1,500 mg
Green Tea Extract (50% EGCG)
BotanicalA leaf extract of Camellia sinensis concentrated for catechins, especially EGCG, with a small amount of naturally occurring caffeine.
Typical: 300–500 mg
Elderberry Extract
BotanicalAn extract of black elderberry fruit standardized to anthocyanins, the dark purple pigments, and one of the most popular immune-season botanicals.
Typical: 300–1,200 mg
Vitamin E (d-Alpha-Tocopheryl Succinate)
VitaminThe succinate ester of natural (RRR or d-) alpha-tocopherol, the one vitamin E form the body maintains in plasma and the form on which the RDA is based.
Typical: 67–268 mg
Greens Blend (Generic)
OtherA generic greens blend is a placeholder for the dried plant powders typical of greens products: cereal grasses such as wheatgrass and barley grass, spirulina and chlorella, leafy vegetables like spinach and kale, and often fruit or vegetable extracts.
Typical: 3–10 g
L-Selenomethionine
MineralThe organic selenium form found in Brazil nuts, grains, and selenium yeast, in which selenium replaces sulfur in the amino acid methionine.
Typical: 50–200 mcg
Alpha-Lipoic Acid (racemic)
AntioxidantAlpha-lipoic acid is a sulfur-containing compound that serves as a mitochondrial enzyme cofactor and a water- and fat-soluble antioxidant.
Typical: 300–600 mg
N-Acetyl-Cysteine (NAC)
Amino acidAn acetylated form of the amino acid cysteine that is the rate-limiting precursor for glutathione, the body's principal intracellular antioxidant.
Typical: 600–1,800 mg
Lutein
AntioxidantLutein is a yellow xanthophyll carotenoid that concentrates in the macula of the eye, where it filters blue light and quenches reactive oxygen species.
Typical: 10–20 mg
Trans-Resveratrol
AntioxidantTrans-resveratrol is a stilbene polyphenol found in grape skin, red wine, and, in far higher concentration, Japanese knotweed root, which is the usual commercial source.
Typical: 150–500 mg
Milk Thistle Extract (80% Silymarin)
BotanicalA seed extract of milk thistle standardized to silymarin, a flavonolignan complex, and the best-known botanical in liver-support formulas.
Typical: 140–420 mg
CoQ10 (Ubiquinol)
AntioxidantUbiquinol is the reduced, active antioxidant form of coenzyme Q10 and the form that predominates in blood.
Typical: 100–200 mg
Astaxanthin
AntioxidantAstaxanthin is a red keto-carotenoid produced by the microalga Haematococcus pluvialis and responsible for the pink color of salmon and krill.
Typical: 4–12 mg
Quercetin Dihydrate
AntioxidantQuercetin dihydrate is the standard crystalline form of the flavonol quercetin, typically extracted from Sophora japonica flower buds and supplied at 95% or higher purity.
Typical: 500–1,000 mg
Spirulina
OtherSpirulina is a dried cyanobacterium (Arthrospira platensis or A.
Typical: 1–5 g
Aged Garlic Extract
BotanicalAged garlic extract is produced by soaking sliced garlic in aqueous ethanol for many months, a process that converts harsh, unstable sulfur compounds into odorless, water-soluble ones such as S-allylcysteine.
Typical: 600–1,200 mg
Black Seed Oil (Nigella sativa)
Fatty acidBlack seed oil is cold-pressed from Nigella sativa seeds, a spice with a long history of traditional use across the Middle East and South Asia.
Typical: 500–2,000 mg
Turmeric Root Powder
BotanicalThe whole dried and ground rhizome of the turmeric plant, the same material used as a culinary spice.
Typical: 1,000–3,000 mg
Zeaxanthin
AntioxidantZeaxanthin is a xanthophyll carotenoid and structural isomer of lutein that concentrates in the central macula.
Typical: 2–4 mg
Zinc Citrate
MineralA zinc salt of citric acid with a relatively high zinc content of about 31%, giving it a compactness advantage over gluconate and picolinate.
Typical: 10–25 mg
Vitamin C (Sodium Ascorbate)
VitaminSodium ascorbate is the sodium salt of ascorbic acid.
Typical: 250–1,000 mg
Ceylon Cinnamon Bark Powder
BotanicalThe ground inner bark of Cinnamomum verum, the Sri Lankan species preferred for supplements because it contains far less coumarin than cassia cinnamon.
Typical: 1,000–3,000 mg
Chlorella
OtherChlorella is a single-celled freshwater green alga, most commonly Chlorella vulgaris, grown in tanks and dried into a fine green powder.
Typical: 2–5 g
Beta-Carotene
VitaminBeta-carotene is an orange plant pigment that the body can split into retinol as needed, which is why it is called provitamin A.
Typical: 3–15 mg
Copper Bisglycinate
MineralCopper chelated with two glycine molecules, supplying about 25% elemental copper in commercial grades.
Typical: 0.5–2 mg
Grape Seed Extract
BotanicalGrape seed extract is a concentrated polyphenol fraction prepared from the seeds left over after winemaking or juice pressing.
Typical: 150–300 mg
Lycopene
AntioxidantLycopene is the red carotenoid that gives tomatoes, watermelon, and pink grapefruit their color.
Typical: 10–30 mg
Green Coffee Bean Extract
BotanicalGreen coffee bean extract is made from unroasted coffee beans, which retain far more chlorogenic acid than roasted coffee.
Typical: 200–400 mg
DIM (Diindolylmethane)
BotanicalDiindolylmethane is the acid-condensation product of indole-3-carbinol, a compound released when cruciferous vegetables such as broccoli and cabbage are chewed.
Typical: 100–300 mg
Olive Leaf Extract
BotanicalOlive leaf extract is prepared from the leaves of Olea europaea and standardized to oleuropein, the bitter secoiridoid that also gives olive oil part of its character.
Typical: 500–1,000 mg
Pine Bark Extract (95% OPC)
BotanicalPine bark extract is a polyphenol-rich extract of French maritime pine (Pinus pinaster) bark, standardized to oligomeric proanthocyanidins (OPCs).
Typical: 50–200 mg
Bilberry Extract
BotanicalBilberry is a European relative of the blueberry whose fruit is rich in anthocyanins, the purple pigments studied for eye and vascular support.
Typical: 80–320 mg
Chaga (Inonotus obliquus)
MushroomChaga is not a true fruiting body but a sclerotium, a dense black mass that grows on birch trees.
Typical: 500–1,500 mg
Copper Gluconate
MineralA copper salt of gluconic acid, about 14% elemental copper, and one of the most widely used copper sources in multivitamins because it is water soluble, inexpensive, and has a long safety record.
Typical: 0.5–2 mg
Fruit & Vegetable Blend (Generic)
OtherA generic fruit and vegetable blend is a placeholder for the dried powders and juice concentrates of fruits, berries, and vegetables that appear in multivitamins, greens products, and whole-food-positioned formulas.
Typical: 1–5 g
Sodium Selenite
MineralAn inorganic selenium salt that is about 46% selenium by weight, inexpensive, and readily converted to selenide for selenoprotein synthesis.
Typical: 50–200 mcg
Vitamin E (Mixed Tocopherols)
VitaminA natural oil concentrate containing all four tocopherols (alpha, beta, gamma, delta) in roughly the proportions found in vegetable oils, usually with gamma-tocopherol dominant.
Typical: 100–400 mg
Curcumin with Turmeric Essential Oils (BCM-95)
BotanicalA branded turmeric extract that recombines curcuminoids with turmeric essential oil (turmerones) rather than using a synthetic carrier.
Typical: 500–1,000 mg
Manganese Bisglycinate
MineralManganese chelated with glycine, about 15% elemental manganese in commercial grades, used in bone, joint, and antioxidant formulas where manganese serves as a cofactor for enzymes involved in cartilage and bone matrix formation.
Typical: 1–5 mg
Pomegranate Extract
BotanicalAn extract of pomegranate fruit or peel standardized to punicalagins or ellagic acid, the polyphenols responsible for its antioxidant reputation, used in heart, antioxidant, and exercise-recovery formulas.
Typical: 500–1,000 mg
Quercetin Phytosome (Quercefit)
AntioxidantQuercetin phytosome is quercetin complexed with sunflower lecithin phospholipids, sold as Quercefit by Indena.
Typical: 250–500 mg
R-Alpha-Lipoic Acid (Na-R-ALA)
AntioxidantR-alpha-lipoic acid is the naturally occurring enantiomer of lipoic acid, the form made in mitochondria and used as a cofactor for energy-producing enzymes.
Typical: 100–300 mg
Vitamin C (Calcium Ascorbate)
VitaminCalcium ascorbate is the calcium salt of vitamin C, commonly supplied as the dihydrate.
Typical: 250–1,000 mg
Yerba Mate Extract
BotanicalYerba mate is the leaf of Ilex paraguariensis, brewed as a tea across South America.
Typical: 500–1,500 mg
Moringa Leaf Powder
BotanicalMoringa is the dried, milled leaf of Moringa oleifera, a fast-growing tree cultivated across South Asia and Africa.
Typical: 1–3 g
Sulforaphane (Broccoli Seed Extract with Myrosinase)
BotanicalSulforaphane is the isothiocyanate formed when glucoraphanin from broccoli seeds or sprouts meets the enzyme myrosinase.
Typical: 100–400 mg
Manganese Gluconate
MineralA water-soluble manganese salt of gluconic acid with about 11–12% elemental manganese, common in multivitamins and bone formulas as an inexpensive, mild-tasting source.
Typical: 1–5 mg
PQQ (Pyrroloquinoline Quinone)
AntioxidantPyrroloquinoline quinone is a redox cofactor found in trace amounts in foods such as natto, kiwi, and green tea.
Typical: 10–20 mg
Hibiscus Flower Extract
BotanicalAn extract of the deep red calyces of Hibiscus sabdariffa, the plant behind hibiscus tea, used in heart-health and hydration formulas.
Typical: 500–1,000 mg
Wheatgrass Powder
OtherWheatgrass is the young leaf of the wheat plant, harvested before the grain forms and dried into a bright green powder or freeze-dried juice powder.
Typical: 3–5 g
Hesperidin
AntioxidantHesperidin is the main flavanone glycoside of orange peel and is the principal component of most citrus bioflavonoid complexes.
Typical: 500 mg
Molybdenum Glycinate
MineralMolybdenum chelated with glycine, one of the forms NIH ODS lists for supplements along with sodium molybdate and molybdenum chloride, with no comparative bioavailability data among them.
Typical: 45–150 mcg
Zinc Monomethionine
MineralA complex of zinc with the amino acid L-methionine, best known under the OptiZinc trade name, carrying roughly 21% elemental zinc.
Typical: 10–25 mg
Barley Grass Powder
OtherBarley grass is the young leaf of Hordeum vulgare, harvested before the plant heads and dried or juiced into a green powder.
Typical: 3–5 g
Pterostilbene
AntioxidantPterostilbene is a methylated analog of resveratrol found in blueberries and Pterocarpus wood.
Typical: 50–250 mg
Rutin
AntioxidantRutin is the glycoside of quercetin bound to the sugar rutinose, usually extracted from Sophora japonica or buckwheat.
Typical: 250–500 mg
Tocotrienols
VitaminTocotrienols are the four unsaturated members of the vitamin E family (alpha, beta, gamma, delta), distinguished from tocopherols by a three-double-bond side chain that lets them move through membranes more freely.
Fisetin
AntioxidantFisetin is a flavonol found in strawberries, apples, and onions and extracted commercially from smoke tree (Cotinus coggygria) or wax tree wood.
Typical: 100–500 mg
Luteolin
AntioxidantLuteolin is a flavone found in celery, parsley, peppers, and chamomile that is studied for mast-cell stabilization and neuro-inflammatory signaling.
Typical: 100 mg
Vitamin C (Ascorbyl Palmitate)
VitaminAscorbyl palmitate is an ester of ascorbic acid and palmitic acid that is soluble in fat rather than water.