Nitrosigine (Inositol-Stabilized Arginine Silicate)
Also known as: Nitrosigine, inositol-stabilized arginine silicate, ASI, arginine silicate inositol, bonded arginine silicate
Nitrosigine is a patented complex of L-arginine bound with silicate and stabilized by inositol, developed by Nutrition21. The complex raises plasma arginine more durably than plain arginine and is marketed for blood flow, pumps, and cognitive performance. A randomized crossover trial found 1.5 g increased flow-mediated dilation by about 31% within an hour, comparable to 8 g of citrulline malate, and acute cognitive studies report improved memory scores. It is used in pre-workouts and nootropic formulas.
Research summary
Supplies arginine for endothelial nitric oxide synthesis with silicate and inositol improving stability and duration of plasma arginine elevation.
Dosage
Daily amounts, of compound.
| Lowest studied | Typical range | Highest studied | Upper limit |
|---|---|---|---|
| 1,500 mg | 1,500 mg | 1,500 mg | — |
1,500 mg once daily, taken 30–60 minutes before exercise or a cognitive task; this is the dose used across the branded trials. It is a fixed-dose ingredient, so partial doses are not supported by data.
Standardization: inositol-stabilized arginine silicate complex (Nitrosigine)
Source material: synthetic complex of L-arginine, silicon, and inositol
Format suitability
- Capsule
- Powder
- Tablet
- Softgel
- Gummy
- Liquid
Water-soluble, mildly bitter powder; flavored pre-workout powders, capsules, and tablets are standard. Gummies feasible at 1.5 g with multiple pieces.
Formulation notes
Additive vasodilation with nitrates, PDE-5 inhibitors, and blood-pressure medication. Can replace or stack with citrulline.
Sources
Related ingredients
L-Citrulline
Sports performanceA non-protein amino acid that the kidneys convert to arginine, raising plasma arginine more efficiently than oral arginine itself.
Typical: 6–8 g
L-Arginine
Amino acidA conditionally essential amino acid and the direct substrate for nitric-oxide synthase.
Typical: 3–6 g
Beet Root Extract (Standardized Nitrate)
BotanicalA concentrated beet root extract standardized to a declared nitrate content so that a nitric-oxide dose can be delivered in a capsule or small scoop instead of gram-level powder.
Typical: 300–500 mg
Caffeine Anhydrous
Sports performancePurified, dehydrated caffeine — the standard stimulant in pre-workouts, energy, and focus products.
Typical: 100–200 mg
Beta-Alanine
Sports performanceA non-essential amino acid that combines with histidine to form carnosine, the main intramuscular buffer of hydrogen ions during intense exercise.
Typical: 3.2–6.4 g