Probiotic Blend (Multi-Strain)
Also known as: multi-strain probiotic, probiotic blend, broad-spectrum probiotic, multispecies probiotic
A generic placeholder for a multi-strain probiotic blend, typically combining several Lactobacillus and Bifidobacterium species and sometimes Streptococcus thermophilus or a Bacillus spore. Meta-analyses of probiotics in irritable bowel syndrome include many multi-strain products dosed between 10 and 50 billion CFU per day, though evidence for blends as a class is less specific than for individual strains. Use this row when the exact strain list will be finalized with the manufacturer; the CFU total, not the number of strains, drives raw-material weight. Replace it with individual strain rows once the formula is set.
Research summary
Combined strains are studied for complementary effects on gut transit, fermentation, and mucosal immunity.
Dosage
Daily amounts, of compound. CFU shown in billions.
| Lowest studied | Typical range | Highest studied | Upper limit |
|---|---|---|---|
| — | 10–50 B CFU | — | — |
Amounts are total billions of CFU across all strains (enter 25 for 25 billion). Raw-material weight assumes a 100 billion CFU/g blended concentrate (10 mg per billion CFU); manufacturers add a 20–50% CFU overage at fill so the label claim holds through shelf life, and the label should state whether CFU are guaranteed at manufacture or at expiry. Blends of vegetative strains should be capsule or powder only.
Standardization: Each strain designated with CFU contribution; total CFU per gram on CoA
Source material: freeze-dried culture
As supplied: Assumes 100 billion CFU/g blended concentrate (10 mg per billion CFU); adjust to the blend CoA.
Format suitability
- Capsule
- Powder
- Tablet
- Softgel
- Gummy
- Liquid
Heat- and moisture-sensitive vegetative cells; capsule or dry powder only unless the blend is built entirely from spore-formers.
Formulation notes
Separate from antibiotic dosing by at least two hours. Keep water activity low; hygroscopic co-ingredients shorten viability.
Sources
- NIH ODS — Probiotics Fact Sheet for Health ProfessionalsNIH ODS
- The efficacy and safety of probiotics in patients with irritable bowel syndrome: Evidence based on 35 randomized controlled trials. (Niu 2020)PubMed
- Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis. (Goodoory 2023)PubMed
Related ingredients
Greens Blend (Generic)
OtherA generic greens blend is a placeholder for the dried plant powders typical of greens products: cereal grasses such as wheatgrass and barley grass, spirulina and chlorella, leafy vegetables like spinach and kale, and often fruit or vegetable extracts.
Typical: 3–10 g
Cranberry Extract (36 mg PACs)
BotanicalCranberry extract is prepared from the whole fruit or juice of Vaccinium macrocarpon and is characterized by A-type proanthocyanidins (PACs) that are studied for anti-adhesion activity against bacteria in the urinary tract.
Typical: 250–500 mg
D-Mannose
OtherD-mannose is a naturally occurring simple sugar related to glucose, found in cranberries and other fruits and made commercially from corn or wood sugars.
Typical: 1–2 g
Vitamin D3 (Cholecalciferol)
VitaminThe form of vitamin D the body makes from sunlight and the most effective supplemental form for raising blood levels.
Typical: 1,000–2,000 IU
Vitamin C (Ascorbic Acid)
VitaminAscorbic acid is the reference form of vitamin C and the most common form in supplements; NIH ODS notes its bioavailability equals that of vitamin C naturally present in food.
Typical: 250–1,000 mg