Best ingredients for gut & digestion
Digestive comfort, microbiome, and regularity. These ingredients are studied for or commonly used for gut & digestion. Doses on each page come from NIH guidance and published research.
Probiotic Blend (Multi-Strain)
ProbioticA generic placeholder for a multi-strain probiotic blend, typically combining several Lactobacillus and Bifidobacterium species and sometimes Streptococcus thermophilus or a Bacillus spore.
Typical: 10–50 B CFU
Magnesium Citrate
MineralMagnesium bound to citric acid, one of the best-selling magnesium forms because it is inexpensive, dissolves readily, and has shown good bioavailability in comparison studies.
Typical: 150–350 mg
Lactobacillus rhamnosus GG (LGG)
ProbioticLGG (Lactobacillus rhamnosus GG, ATCC 53103) is the single most studied probiotic strain, isolated in 1985 and since reclassified as Lacticaseibacillus rhamnosus.
Typical: 1–10 B CFU
Berberine HCl
BotanicalAn isoquinoline alkaloid isolated from plants such as barberry, goldenseal, and Coptis, supplied as the hydrochloride salt.
Typical: 900–1,500 mg
Bifidobacterium lactis
ProbioticBifidobacterium animalis subsp.
Typical: 1–10 B CFU
Magnesium Oxide
MineralThe most concentrated magnesium source at about 60% elemental magnesium, which is why it dominates in multivitamins and small tablets.
Typical: 200–350 mg
Inulin (Chicory Root Fiber)
PrebioticInulin is a soluble, fermentable fructan fiber extracted mainly from chicory root, though it also occurs in Jerusalem artichoke, agave, and onions.
Typical: 5–10 g
Piperine (Black Pepper Extract 95%)
BotanicalThe pungent alkaloid isolated from black pepper fruit, used in tiny amounts to raise the absorption of other ingredients rather than for its own effects.
Typical: 5–20 mg
Ginger Root Extract
BotanicalA concentrated extract of ginger rhizome standardized to gingerols, the pungent compounds responsible for most of its studied effects.
Typical: 250–1,000 mg
L-Glutamine
Amino acidThe most abundant free amino acid in blood and muscle and a primary fuel for intestinal and immune cells.
Typical: 5–10 g
Saccharomyces boulardii
ProbioticSaccharomyces boulardii is a probiotic yeast rather than a bacterium, originally isolated from lychee and mangosteen skins.
Typical: 5–10 B CFU
Greens Blend (Generic)
OtherA generic greens blend is a placeholder for the dried plant powders typical of greens products: cereal grasses such as wheatgrass and barley grass, spirulina and chlorella, leafy vegetables like spinach and kale, and often fruit or vegetable extracts.
Typical: 3–10 g
Lactobacillus acidophilus
ProbioticLactobacillus acidophilus is the most widely recognized probiotic species and a staple of yogurt cultures and multi-strain capsules.
Typical: 1–10 B CFU
Bacillus coagulans
ProbioticBacillus coagulans is a spore-forming, lactic-acid-producing bacterium whose spores survive stomach acid, heat, and dry storage far better than vegetative Lactobacillus cells.
Typical: 1–2 B CFU
Bifidobacterium longum
ProbioticBifidobacterium longum is one of the dominant bifidobacteria of the adult human colon.
Typical: 1–10 B CFU
Psyllium Husk
PrebioticPsyllium husk is the seed coat of Plantago ovata, a soluble, gel-forming fiber that holds many times its weight in water.
Typical: 5–10 g
Lactobacillus reuteri (DSM 17938)
ProbioticLactobacillus reuteri is a native human gut and breast-milk organism, now classified as Limosilactobacillus reuteri.
Typical: 0.1–1 B CFU
Milk Thistle Extract (80% Silymarin)
BotanicalA seed extract of milk thistle standardized to silymarin, a flavonolignan complex, and the best-known botanical in liver-support formulas.
Typical: 140–420 mg
Cranberry Extract (36 mg PACs)
BotanicalCranberry extract is prepared from the whole fruit or juice of Vaccinium macrocarpon and is characterized by A-type proanthocyanidins (PACs) that are studied for anti-adhesion activity against bacteria in the urinary tract.
Typical: 250–500 mg
Chamomile Flower Extract
BotanicalAn extract of German chamomile flowers standardized to apigenin, the flavone behind much of its calming reputation.
Typical: 220–1,100 mg
Lactase (Beta-Galactosidase)
EnzymeLactase splits milk sugar (lactose) into glucose and galactose.
Lactobacillus plantarum
ProbioticLactobacillus plantarum is a versatile lactic acid bacterium found in fermented vegetables and sourdough, now classified as Lactiplantibacillus plantarum.
Typical: 1–10 B CFU
Boswellia Serrata Extract (65% Boswellic Acids)
BotanicalA gum resin extract from the Boswellia serrata tree standardized to total boswellic acids, used in joint-comfort formulas often alongside curcumin.
Typical: 300–500 mg
Bifidobacterium infantis (35624)
ProbioticBifidobacterium infantis, now classified as B.
Typical: 1–10 B CFU
Bifidobacterium bifidum
ProbioticBifidobacterium bifidum is a mucin-degrading species that is abundant in breast-fed infants and declines with age.
Typical: 1–5 B CFU
Bromelain
EnzymeBromelain is a mixture of protein-digesting enzymes extracted from pineapple stem.
Typical: 200–500 mg
Fructooligosaccharides (FOS)
PrebioticFructooligosaccharides are short-chain fructans produced either by partial hydrolysis of chicory inulin (oligofructose) or by enzymatic synthesis from sucrose (scFOS).
Typical: 2.5–10 g
Turmeric Root Powder
BotanicalThe whole dried and ground rhizome of the turmeric plant, the same material used as a culinary spice.
Typical: 1,000–3,000 mg
Peppermint Oil (Enteric-Coated)
BotanicalPeppermint oil is the steam-distilled essential oil of Mentha piperita, rich in menthol and menthone.
Typical: 180–450 mg
Protease (Fungal Protease Blend)
EnzymeProtease is a family of enzymes that cleave peptide bonds, breaking dietary proteins into peptides and amino acids.
Typical: 50–150 mg
Acacia Fiber (Gum Arabic)
PrebioticAcacia fiber is the dried sap of Acacia senegal and Acacia seyal trees, a highly branched arabinogalactan polysaccharide that dissolves completely in water with almost no viscosity.
Typical: 5–10 g
Amylase (Fungal Alpha-Amylase)
EnzymeAmylase is the enzyme that breaks starch into maltose and shorter glucose chains.
Typical: 50–150 mg
Lactobacillus casei
ProbioticLactobacillus casei is a lactic acid bacterium closely related to L.
Typical: 1–10 B CFU
Partially Hydrolyzed Guar Gum (PHGG)
PrebioticPartially hydrolyzed guar gum is guar bean galactomannan that has been enzymatically shortened so it dissolves clear and non-viscous instead of forming a thick gel.
Typical: 5–6 g
Lipase (Fungal Lipase)
EnzymeLipase hydrolyzes dietary triglycerides into free fatty acids and monoglycerides so they can be absorbed.
Typical: 30–100 mg
Galactooligosaccharides (GOS)
PrebioticGalactooligosaccharides are chains of galactose units produced enzymatically from lactose, which makes them structurally similar to some of the oligosaccharides in human milk.
Typical: 2.5–5 g
Turkey Tail (Trametes versicolor)
MushroomTurkey tail is a thin, fan-shaped polypore whose protein-bound polysaccharides (PSK and PSP) have been studied for decades in Japan and China as adjuncts in oncology settings.
Typical: 1,000–3,000 mg
Betaine HCl
EnzymeBetaine hydrochloride is the acidic salt of trimethylglycine, a dry crystalline powder that releases hydrochloric acid when it dissolves in the stomach.
Typical: 500–1,500 mg
D-Mannose
OtherD-mannose is a naturally occurring simple sugar related to glucose, found in cranberries and other fruits and made commercially from corn or wood sugars.
Typical: 1–2 g
Lactobacillus gasseri
ProbioticLactobacillus gasseri is a human-origin lactic acid bacterium found in the gut and vaginal microbiota.
Typical: 1–10 B CFU
Oregano Oil
BotanicalOregano oil is the steam-distilled essential oil of Origanum vulgare, standardized to carvacrol, its dominant phenolic compound, at around 70 percent.
Typical: 150–300 mg
Resistant Starch
PrebioticResistant starch is starch that escapes digestion in the small intestine and is fermented in the colon, where it is a preferred substrate for butyrate-producing bacteria.
Typical: 10–20 g
Alpha-Galactosidase
EnzymeAlpha-galactosidase breaks down the raffinose-family oligosaccharides in beans, lentils, cruciferous vegetables, and whole grains that humans cannot digest and that otherwise ferment into gas in the colon.
Bacillus subtilis DE111
ProbioticDE111 is a trademarked strain of Bacillus subtilis, a spore-forming soil and gut organism, supplied by Deerland (now part of ADM).
Typical: 1–5 B CFU
Aloe Vera Inner Leaf Extract (200:1)
BotanicalAloe vera inner leaf extract is the dried, decolorized gel of Aloe barbadensis, supplied as a 200:1 concentrate so that 50 to 200 mg represents 10 to 40 g of fresh gel.
Typical: 50–200 mg
Xylooligosaccharides (XOS)
PrebioticXylooligosaccharides are short chains of xylose produced by enzymatic breakdown of xylan from corn cobs or other plant cell walls.
Typical: 1,000–2,000 mg
Streptococcus thermophilus
ProbioticStreptococcus thermophilus is one of the two mandatory yogurt starter cultures and a source of the enzyme lactase (beta-galactosidase).
Typical: 1–5 B CFU
Artichoke Leaf Extract
BotanicalAn extract of globe artichoke leaves standardized to cynarin and caffeoylquinic acids, used in digestive, liver, and cholesterol-support formulas.
Typical: 320–640 mg
Tributyrin
OtherTributyrin is a triglyceride made of three butyrate molecules bound to glycerol.
Typical: 300–1,000 mg
Cellulase
EnzymeCellulase breaks the beta-1,4 bonds of cellulose, the structural fiber in plant cell walls that human digestive enzymes cannot touch.
DGL Licorice (Deglycyrrhizinated)
BotanicalDGL is licorice root extract from which most of the glycyrrhizin has been removed, typically to below 1 to 3 percent.
Typical: 380–760 mg
Ox Bile Extract
EnzymeOx bile extract is dried, defatted bovine bile that supplies conjugated bile salts such as taurocholate and glycocholate.
Typical: 100–500 mg
Senna Leaf Extract (Sennosides)
BotanicalSenna is the leaf or pod of Senna alexandrina, standardized to sennosides, which are anthraquinone glycosides converted by gut bacteria into compounds that stimulate colon movement.
Typical: 15–30 mg
Dandelion Root
BotanicalThe root of the common dandelion, used in traditional practice as a bitter digestive and liver tonic and in modern formulas for liver support and water balance.
Typical: 500–2,000 mg
Barley Grass Powder
OtherBarley grass is the young leaf of Hordeum vulgare, harvested before the plant heads and dried or juiced into a green powder.
Typical: 3–5 g
Slippery Elm Bark
BotanicalSlippery elm is the inner bark of Ulmus rubra, a North American tree.
Typical: 400–1,500 mg
Marshmallow Root
BotanicalMarshmallow root is the dried root of Althaea officinalis, a European plant unrelated to the confection that borrowed its name.
Typical: 500–1,500 mg
Fennel Seed
BotanicalFennel seed is the dried fruit of Foeniculum vulgare, a Mediterranean herb used across cuisines and in traditional carminative blends for bloating and gas.
Typical: 500–1,500 mg
Papain
EnzymePapain is a cysteine protease obtained from the latex of unripe papaya fruit.
Typical: 100–300 mg