Artichoke Leaf Extract
Also known as: Cynara scolymus, Cynara cardunculus, artichoke extract, cynarin
An extract of globe artichoke leaves standardized to cynarin and caffeoylquinic acids, used in digestive, liver, and cholesterol-support formulas. A twelve-week randomized trial at 1,280 mg per day reported lower total cholesterol in adults with mildly elevated levels, and a meta-analysis of nine trials found reductions in total and LDL cholesterol and triglycerides. It is also a classic bitter for digestive comfort and pairs naturally with milk thistle.
Research summary
Caffeoylquinic acids and luteolin glycosides increase bile secretion and inhibit hepatic cholesterol synthesis, and act as antioxidants.
Dosage
Daily amounts, of extract.
| Lowest studied | Typical range | Highest studied | Upper limit |
|---|---|---|---|
| — | 320–640 mg | 1,280 mg | — |
320 to 640 mg per day of a 5% cynarin extract, split with meals; the cholesterol trial used 1,280 mg per day for twelve weeks. Digestive effects are noticed within days, lipid effects over weeks.
Standardization: 5% cynarin (or 13–18% caffeoylquinic acids)
Source material: leaf extract
Format suitability
- Capsule
- Powder
- Tablet
- Softgel
- Gummy
- Liquid
Bitter; capsules preferred, though liquid bitters are traditional.
Formulation notes
Often combined with milk thistle, dandelion, or ginger. Ragweed-family plant; increases bile flow, so avoid in gallstone-related positioning.
Sources
Related ingredients
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Psyllium Husk
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Milk Thistle Extract (80% Silymarin)
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Typical: 140–420 mg
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