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Manganese Bisglycinate

MineralModerate dose evidence

Also known as: manganese glycinate, chelated manganese, manganese bis-glycinate chelate, manganese amino acid chelate

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Manganese chelated with glycine, about 15% elemental manganese in commercial grades, used in bone, joint, and antioxidant formulas where manganese serves as a cofactor for enzymes involved in cartilage and bone matrix formation. NIH ODS lists bisglycinate among the common supplemental forms and notes there are no data comparing bioavailability across forms. Because dietary intake is already adequate for most people and the UL is 11 mg, supplemental doses are small.

Research summary

Supplies manganese for manganese superoxide dismutase, glycosyltransferases used in proteoglycan synthesis, and enzymes of carbohydrate and amino acid metabolism.

BoneJointAntioxidantGeneral health

Dosage

Daily amounts, elemental (15% of the compound is the element).

Lowest studiedTypical rangeHighest studiedUpper limit
1 mg1–5 mg—11 mg

NIH ODS — UL of 11 mg/day for adults from all sources

Doses are milligrams of elemental manganese. Commercial bisglycinate is specified at roughly 15% manganese (pure bis-glycinate stoichiometry ≈ 27%; buffered grades are lower) — verify against the supplier's certificate of analysis. ODS reports multivitamins provide 1–4.5 mg and manganese-only products 5–20 mg; the adult AI is 1.8–2.3 mg and the UL is 11 mg. A highest studied supplemental dose was not located. Take with food.

Source material: synthetic chelate (manganese with glycine)

As supplied: ≈ 15% Mn; 2 mg elemental ≈ 13 mg compound

Forms of Manganese

FormTypical doseElement %FormatsPrice
Manganese Bisglycinate1–5 mg15%Capsule, Powder, Tablet, Gummy, Liquidlow
Manganese Gluconate1–5 mg12%Capsule, Powder, Tablet, Gummy, Liquidlow

Format suitability

  • Capsule
  • Powder
  • Tablet
  • Softgel
  • Gummy
  • Liquid

Tiny dose; blend uniformity is the only practical concern.

Formulation notes

Iron, calcium, and phosphorus in the same serving can reduce manganese absorption, and manganese competes with iron for uptake. Keep formulas modest, since diet already supplies 2–5 mg/day and manganese accumulates in people with liver impairment.

  • Has an upper limit

Sources

  1. Manganese — Health Professional Fact SheetNIH ODS
  2. Manganese in the Diet: Bioaccessibility, Adequate Intake, and Neurotoxicological Effects (Martins 2020)PubMed

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