Manganese Gluconate
Also known as: Mn gluconate, manganese D-gluconate
A water-soluble manganese salt of gluconic acid with about 11–12% elemental manganese, common in multivitamins and bone formulas as an inexpensive, mild-tasting source. NIH ODS lists it among standard supplemental forms with no comparative bioavailability data. Diets already supply several milligrams of manganese daily, so supplements usually add only a milligram or two, and the 11 mg adult UL is a meaningful ceiling for high-potency products.
Research summary
Supplies manganese for antioxidant (Mn-SOD), connective-tissue, and metabolic enzymes.
Dosage
Daily amounts, elemental (12% of the compound is the element).
| Lowest studied | Typical range | Highest studied | Upper limit |
|---|---|---|---|
| 1 mg | 1–5 mg | — | 11 mg |
NIH ODS — UL of 11 mg/day for adults from all sources
Doses are milligrams of elemental manganese. Manganese gluconate anhydrous (C12H22MnO14, MW 445.2) is 12.3% Mn (54.94 ÷ 445.2) and the dihydrate (MW 481.3) is 11.4%; 0.116 is used as a commercial midpoint — verify against the supplier's certificate of analysis. Adult AI 1.8–2.3 mg; UL 11 mg. A highest studied supplemental dose was not located. Take with food.
Source material: synthetic (manganese carbonate reacted with gluconic acid)
As supplied: ≈ 11–12% Mn depending on hydration
Forms of Manganese
| Form | Typical dose | Element % | Formats | Price |
|---|---|---|---|---|
| Manganese Gluconate | 1–5 mg | 12% | Capsule, Powder, Tablet, Gummy, Liquid | low |
| Manganese Bisglycinate | 1–5 mg | 15% | Capsule, Powder, Tablet, Gummy, Liquid | low |
Format suitability
- Capsule
- Powder
- Tablet
- Softgel
- Gummy
- Liquid
Tiny dose; soluble, faint pink tint in concentrated premixes.
Formulation notes
Iron, calcium, and phosphorus in the same serving can reduce manganese absorption, and manganese competes with iron for uptake. Keep formulas modest, since diet already supplies 2–5 mg/day and manganese accumulates in people with liver impairment.
- Has an upper limit
Sources
Related ingredients
Manganese Bisglycinate
MineralManganese chelated with glycine, about 15% elemental manganese in commercial grades, used in bone, joint, and antioxidant formulas where manganese serves as a cofactor for enzymes involved in cartilage and bone matrix formation.
Typical: 1–5 mg
Calcium (Microcrystalline Hydroxyapatite, MCHC)
MineralA whole-bone extract made from bovine bone that keeps the natural hydroxyapatite mineral matrix together with collagen and other bone proteins.
Typical: 250–700 mg
Vitamin D3 (Cholecalciferol)
VitaminThe form of vitamin D the body makes from sunlight and the most effective supplemental form for raising blood levels.
Typical: 1,000–2,000 IU
Fish Oil (EPA/DHA Concentrate)
Fatty acidFish oil concentrate is a refined marine oil enriched in the long-chain omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
Typical: 500–2,000 mg
Vitamin C (Ascorbic Acid)
VitaminAscorbic acid is the reference form of vitamin C and the most common form in supplements; NIH ODS notes its bioavailability equals that of vitamin C naturally present in food.
Typical: 250–1,000 mg