Quercetin Phytosome (Quercefit)

AntioxidantflavonolBranded: Quercefit (Indena S.p.A.)Moderate dose evidence

Also known as: Quercefit, quercetin phospholipid complex, quercetin lecithin complex

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Quercetin phytosome is quercetin complexed with sunflower lecithin phospholipids, sold as Quercefit by Indena. The complex is designed to overcome the poor water solubility of plain quercetin; the manufacturer's pharmacokinetic study reported substantially higher plasma quercetin exposure than an equal dose of the unformulated compound. It is used in the same immune, cardiovascular, and healthy-aging formulas as quercetin dihydrate but at a lower label dose. About 40% of the complex by weight is quercetin.

Research summary

Phospholipid complexation improves dispersion and absorption of quercetin in the gut.

Dosage

Daily amounts, of compound.

Lowest studiedTypical rangeHighest studiedUpper limit
250 mg250–500 mg

Doses are expressed as the whole phytosome complex, not quercetin content. 250 to 500 mg once or twice daily is the range used in the brand's registry studies.

Standardization: Quercetin-phospholipid complex, approximately 40% quercetin

Source material: Sophora japonica quercetin complexed with sunflower lecithin

Forms of Quercetin

FormTypical doseElement %FormatsPrice
Quercetin Phytosome (Quercefit)250–500 mgCapsule, Powder, Tabletpremium
Quercetin Dihydrate500–1,000 mgCapsule, Powder, Tabletmid

Format suitability

  • Capsule
  • Powder
  • Tablet
  • Softgel
  • Gummy
  • Liquid

Yellow powder; not suited to gummies.

Formulation notes

Contains sunflower lecithin (not a major allergen). Lower mass per serving than plain quercetin simplifies capsule sizing.

Sources

  1. Improved Oral Absorption of Quercetin from Quercetin Phytosome®, a New Delivery System Based on Food Grade Lecithin. (Riva A 2019)PubMed

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