White Willow Bark Extract
Also known as: Salix alba, willow bark, salicin, Salix daphnoides, Salix purpurea
White willow bark is the botanical ancestor of aspirin. Its bark contains salicin, which the body converts to salicylic acid, alongside polyphenols and flavonoids that contribute to its effects. A 4-week RCT of 210 adults with low-back discomfort found extracts delivering 120 mg and 240 mg salicin per day outperformed placebo, with the higher dose acting within a week. It is used in joint, back-comfort, and some weight-management formulas at 15% salicin standardization.
Research summary
Salicin is metabolized to salicylic acid, inhibiting cyclooxygenase; bark polyphenols add antioxidant and anti-inflammatory activity.
Dosage
Daily amounts, of extract.
| Lowest studied | Typical range | Highest studied | Upper limit |
|---|---|---|---|
| 800 mg | 800–1,600 mg | 1,600 mg | — |
Dose by salicin: 120–240 mg per day, which is 800–1,600 mg of a 15% salicin extract, usually split into two doses with food. The 240 mg salicin dose was more effective than 120 mg in the main trial. Onset is slower than aspirin because salicin must be converted by gut bacteria.
Standardization: 15% salicin
Source material: bark extract
Format suitability
- Capsule
- Powder
- Tablet
- Softgel
- Gummy
- Liquid
Bitter and astringent; capsules and tablets standard. Not appropriate for gummies aimed at children.
Formulation notes
Salicylate: avoid with aspirin or salicylate allergy, anticoagulants, NSAIDs, and in children or teens with viral illness (Reye's syndrome risk). Not for use in pregnancy or breastfeeding.
- Notable drug interactions
- Not for pregnancy
Sources
Related ingredients
Fish Oil (EPA/DHA Concentrate)
Fatty acidFish oil concentrate is a refined marine oil enriched in the long-chain omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
Typical: 500–2,000 mg
Curcumin Extract (95% Curcuminoids)
BotanicalA concentrated turmeric rhizome extract standardized to 95% curcuminoids, the form used in most joint and inflammation research.
Typical: 500–1,500 mg
Ginger Root Extract
BotanicalA concentrated extract of ginger rhizome standardized to gingerols, the pungent compounds responsible for most of its studied effects.
Typical: 250–1,000 mg
MSM (Methylsulfonylmethane)
OtherMSM is an organic sulfur compound found in small amounts in plants, milk, and the body.
Typical: 1,500–3,000 mg
Krill Oil
Fatty acidKrill oil is extracted from Antarctic krill (Euphausia superba), a small crustacean.
Typical: 500–2,000 mg