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Bacillus coagulans

Probioticspore-forming probioticStrong dose evidence

Also known as: B. coagulans, GBI-30, 6086, BC30, Heyndrickxia coagulans, Weizmannia coagulans, MTCC 5856, LactoSpore, Unique IS-2, SNZ 1969

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Bacillus coagulans is a spore-forming, lactic-acid-producing bacterium whose spores survive stomach acid, heat, and dry storage far better than vegetative Lactobacillus cells. That resilience makes it the go-to probiotic for gummies, baked goods, hot beverages, and shelf-stable powders. The strain GBI-30, 6086 has randomized trials in healthy adults for gastrointestinal function and in military trainees for muscle integrity and cytokine markers; strain MTCC 5856 has its own program. Typical doses are 1–2 billion spores daily. Spores germinate in the small intestine and are not permanent colonizers.

Research summary

Spores germinate in the intestine to produce L-lactic acid and enzymes; studied for effects on protein digestion, gut comfort, and immune markers.

Gut & digestionImmuneMuscle recovery

Dosage

Daily amounts, of compound. CFU shown in billions.

Lowest studiedTypical rangeHighest studiedUpper limit
1 B CFU1–2 B CFU——

Amounts are in billions of CFU (enter 1 for 1 billion spores). Raw-material weight assumes a 100 billion CFU/g concentrate (10 mg per billion CFU); spore concentrates are often lower potency (for example 15 billion/g), so adjust to the supplier CoA. Manufacturers still add a 20–50% overage for processing losses; state CFU at manufacture or at expiry on the label. Take with food.

Standardization: Strain-designated spore preparation; CFU (spores) per gram on CoA

Source material: freeze-dried culture

As supplied: Assumes 100 billion CFU/g (10 mg per billion CFU); commercial spore concentrates commonly run 15–100 billion CFU/g, so raw-material weight may be several times higher than the default.

Forms of Bacillus

FormTypical doseElement %FormatsPrice
Bacillus coagulans1–2 B CFU—Capsule, Powder, Gummylow
Bacillus subtilis DE1111–5 B CFU—Capsule, Powder, Gummymid

Format suitability

  • Capsule
  • Powder
  • Tablet
  • Softgel
  • Gummy
  • Liquid

Spore-former; tolerates gummy depositing temperatures, tableting, and shelf-stable powders far better than Lactobacillus or Bifidobacterium. Still budget overage for heat losses in gummies.

Formulation notes

Compatible with most matrices including protein powders and hot beverages. Genus was renamed Weizmannia and then Heyndrickxia; all three names refer to the same organism on certificates of analysis.

Sources

  1. NIH ODS — Probiotics Fact Sheet for Health ProfessionalsNIH ODS
  2. Impact of Heyndrickxia (Bacillus) coagulans GBI-30, 6086 (BC30) probiotic on gastrointestinal function in healthy adults: a randomised controlled trial. (Gang 2025)PubMed
  3. Combined effect of Bacillus coagulans GBI-30, 6086 and HMB supplementation on muscle integrity and cytokine response during intense military training. (Gepner 2017)PubMed

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