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Bifidobacterium bifidum

ProbioticbifidobacteriaModerate dose evidence

Also known as: B. bifidum, MIMBb75, Bb-06, BF-688

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Bifidobacterium bifidum is a mucin-degrading species that is abundant in breast-fed infants and declines with age. The strain MIMBb75 was tested in a multicenter randomized trial in irritable bowel syndrome at 1 billion CFU daily, with a later trial using heat-inactivated cells. It is a common component of multi-strain blends for digestive comfort and immune support. B. bifidum is less oxygen-tolerant than B. lactis, so it is usually included at modest counts with adequate overage and moisture protection.

Research summary

Studied for adhesion to intestinal mucin, epithelial barrier support, and modulation of inflammatory signaling.

Gut & digestionImmune

Dosage

Daily amounts, of compound. CFU shown in billions.

Lowest studiedTypical rangeHighest studiedUpper limit
1 B CFU1–5 B CFU——

Amounts are in billions of CFU (enter 1 for 1 billion). Raw-material weight assumes a 100 billion CFU/g concentrate (10 mg per billion CFU); manufacturers add a 20–50% CFU overage at fill so the label claim holds through shelf life, and the label should state whether CFU are guaranteed at manufacture or at expiry. The MIMBb75 IBS trial used 1 billion CFU once daily for four weeks.

Standardization: Strain-designated freeze-dried culture; CFU per gram on CoA

Source material: freeze-dried culture

As supplied: Assumes 100 billion CFU/g concentrate (10 mg per billion CFU); adjust to supplier CoA.

Forms of Bifidobacterium

FormTypical doseElement %FormatsPrice
Bifidobacterium bifidum1–5 B CFU—Capsule, Powdermid
Bifidobacterium lactis1–10 B CFU—Capsule, Powdermid
Bifidobacterium longum1–10 B CFU—Capsule, Powdermid
Bifidobacterium infantis (35624)1–10 B CFU—Capsule, Powderhigh

Format suitability

  • Capsule
  • Powder
  • Tablet
  • Softgel
  • Gummy
  • Liquid

Heat-, oxygen-, and moisture-sensitive; capsule or dry powder only, with desiccant packaging recommended.

Formulation notes

Separate from antibiotic dosing by at least two hours. Keep water activity low in the finished product.

Sources

  1. NIH ODS — Probiotics Fact Sheet for Health ProfessionalsNIH ODS
  2. Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study. (Guglielmetti 2011)PubMed
  3. Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. (Andresen 2020)PubMed

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