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Bifidobacterium longum

ProbioticbifidobacteriaModerate dose evidence

Also known as: B. longum, BB536, Bifidobacterium longum subsp. longum, BL-05, Rosell-175, 1714

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Bifidobacterium longum is one of the dominant bifidobacteria of the adult human colon. The Japanese strain BB536 has decades of use in dairy and supplements and has been tested in randomized trials for immune cell activation in healthy adults and for gut environment and stool outcomes. Other strains, such as 1714 and Rosell-175, are marketed for stress and mood. It is used in daily gut-support and immune blends and is among the more robust Bifidobacterium species for freeze-drying. Strain identity determines which studies apply.

Research summary

Studied for fermentation of dietary fibers to short-chain fatty acids and for interactions with dendritic cells and other immune cells.

Gut & digestionImmuneMood

Dosage

Daily amounts, of compound. CFU shown in billions.

Lowest studiedTypical rangeHighest studiedUpper limit
1 B CFU1–10 B CFU——

Amounts are in billions of CFU (enter 5 for 5 billion). Raw-material weight assumes a 100 billion CFU/g concentrate (10 mg per billion CFU); manufacturers add a 20–50% CFU overage at fill so the label claim holds through shelf life, and the label should state whether CFU are guaranteed at manufacture or at expiry.

Standardization: Strain-designated freeze-dried culture; CFU per gram on CoA

Source material: freeze-dried culture

As supplied: Assumes 100 billion CFU/g concentrate (10 mg per billion CFU); adjust to supplier CoA.

Forms of Bifidobacterium

FormTypical doseElement %FormatsPrice
Bifidobacterium longum1–10 B CFU—Capsule, Powdermid
Bifidobacterium lactis1–10 B CFU—Capsule, Powdermid
Bifidobacterium infantis (35624)1–10 B CFU—Capsule, Powderhigh
Bifidobacterium bifidum1–5 B CFU—Capsule, Powdermid

Format suitability

  • Capsule
  • Powder
  • Tablet
  • Softgel
  • Gummy
  • Liquid

Heat- and moisture-sensitive vegetative cells; capsule or dry powder only.

Formulation notes

Separate from antibiotic dosing by at least two hours. Keep water activity low in the finished product.

Sources

  1. NIH ODS — Probiotics Fact Sheet for Health ProfessionalsNIH ODS
  2. The Potential Immunomodulatory Effect of Bifidobacterium longum subsp. longum BB536 on Healthy Adults through Plasmacytoid Dendritic Cell Activation in the Peripheral Blood. (Li 2023)PubMed
  3. The Impact of Fermented Milk Products Containing Bifidobacterium longum BB536 on the Gut Environment: A Randomized Double-Blind Placebo-Controlled Trial. (Ejima 2024)PubMed

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