Luteolin
Also known as: 3',4',5,7-tetrahydroxyflavone, luteolin 98%, peanut hull extract, perilla flavone
Luteolin is a flavone found in celery, parsley, peppers, and chamomile that is studied for mast-cell stabilization and neuro-inflammatory signaling. Supplement-grade luteolin is usually 98% pure from peanut hulls, perilla, or Sophora. Human data are sparse: an open-label pediatric pilot used a 100 mg luteolin capsule combined with quercetin and rutin, and a small exercise study paired it with mangiferin. It appears in brain-health, allergy-season, and antioxidant blends at around 100 mg.
Research summary
Inhibits mast-cell degranulation and NF-κB signaling in vitro; general flavonoid antioxidant.
Dosage
Daily amounts, of compound.
| Lowest studied | Typical range | Highest studied | Upper limit |
|---|---|---|---|
| — | 100 mg | — | — |
100 mg per serving is the common market dose and matches the 100 mg per capsule used in the open-label combination pilot. No placebo-controlled trial of isolated luteolin supports a specific dose, so confidence is low. Poorly water-soluble; often formulated in oil or with a fat-containing meal.
Standardization: ≥98% luteolin
Source material: peanut (Arachis hypogaea) hull extract or perilla leaf extract
Format suitability
- Capsule
- Powder
- Tablet
- Softgel
- Gummy
- Liquid
Yellow, insoluble powder. Capsules and tablets standard. If peanut-hull derived, evaluate allergen labeling with the supplier even though protein content is negligible.
Formulation notes
Peanut-hull source may raise allergen-labeling questions; confirm origin. Often paired with quercetin and rutin.
Sources
Related ingredients
Fish Oil (EPA/DHA Concentrate)
Fatty acidFish oil concentrate is a refined marine oil enriched in the long-chain omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
Typical: 500–2,000 mg
Curcumin Extract (95% Curcuminoids)
BotanicalA concentrated turmeric rhizome extract standardized to 95% curcuminoids, the form used in most joint and inflammation research.
Typical: 500–1,500 mg
Turmeric Root Powder
BotanicalThe whole dried and ground rhizome of the turmeric plant, the same material used as a culinary spice.
Typical: 1,000–3,000 mg
Black Seed Oil (Nigella sativa)
Fatty acidBlack seed oil is cold-pressed from Nigella sativa seeds, a spice with a long history of traditional use across the Middle East and South Asia.
Typical: 500–2,000 mg
Curcumin Solid Lipid Particle (Longvida)
BotanicalA branded curcumin formulation in which curcumin is embedded in solid lipid particles to protect it from degradation in the gut and support delivery of free curcumin into circulation.
Typical: 400–800 mg