Best ingredients for blood sugar
Glucose metabolism and insulin sensitivity. These ingredients are studied for or commonly used for blood sugar. Doses on each page come from NIH guidance and published research.
Berberine HCl
BotanicalAn isoquinoline alkaloid isolated from plants such as barberry, goldenseal, and Coptis, supplied as the hydrochloride salt.
Typical: 900–1,500 mg
Chromium Picolinate
MineralTrivalent chromium chelated with three picolinate ligands, the form used in most human trials and the best seller in blood-sugar and weight-management formulas.
Typical: 200–500 mcg
Alpha-Lipoic Acid (racemic)
AntioxidantAlpha-lipoic acid is a sulfur-containing compound that serves as a mitochondrial enzyme cofactor and a water- and fat-soluble antioxidant.
Typical: 300–600 mg
Psyllium Husk
PrebioticPsyllium husk is the seed coat of Plantago ovata, a soluble, gel-forming fiber that holds many times its weight in water.
Typical: 5–10 g
Apple Cider Vinegar Powder
OtherApple cider vinegar powder is liquid vinegar spray-dried onto a carrier such as maltodextrin or cyclodextrin so it can be used in capsules and gummies.
Typical: 500–1,500 mg
Myo-Inositol
OtherMyo-inositol is a sugar alcohol the body makes from glucose and the most abundant inositol isomer in cells, where it forms the backbone of phosphatidylinositol signaling lipids and the second messengers that relay insulin and hormone signals.
Typical: 2–4 g
Black Seed Oil (Nigella sativa)
Fatty acidBlack seed oil is cold-pressed from Nigella sativa seeds, a spice with a long history of traditional use across the Middle East and South Asia.
Typical: 500–2,000 mg
Ceylon Cinnamon Bark Powder
BotanicalThe ground inner bark of Cinnamomum verum, the Sri Lankan species preferred for supplements because it contains far less coumarin than cassia cinnamon.
Typical: 1,000–3,000 mg
Fenugreek Seed Extract
BotanicalA generic seed extract of fenugreek, a legume used both as a spice and in traditional medicine.
Typical: 500–600 mg
Green Coffee Bean Extract
BotanicalGreen coffee bean extract is made from unroasted coffee beans, which retain far more chlorogenic acid than roasted coffee.
Typical: 200–400 mg
Resistant Starch
PrebioticResistant starch is starch that escapes digestion in the small intestine and is fermented in the colon, where it is a preferred substrate for butyrate-producing bacteria.
Typical: 10–20 g
Holy Basil (Tulsi) Extract
BotanicalA leaf extract of tulsi, an aromatic basil revered in Ayurvedic tradition and used in modern formulas as a gentle adaptogen for stress and metabolic balance.
Typical: 300–1,000 mg
Gymnema Sylvestre Extract
BotanicalGymnema sylvestre is a climbing vine from India whose leaves contain gymnemic acids, triterpene saponins that temporarily blunt the perception of sweet taste on the tongue.
Typical: 200–400 mg
Aloe Vera Inner Leaf Extract (200:1)
BotanicalAloe vera inner leaf extract is the dried, decolorized gel of Aloe barbadensis, supplied as a 200:1 concentrate so that 50 to 200 mg represents 10 to 40 g of fresh gel.
Typical: 50–200 mg
Mulberry Leaf Extract (DNJ)
BotanicalWhite mulberry leaf contains 1-deoxynojirimycin (DNJ), an iminosugar that inhibits alpha-glucosidase in the gut and slows the breakdown of starch and sucrose.
Typical: 250–500 mg
R-Alpha-Lipoic Acid (Na-R-ALA)
AntioxidantR-alpha-lipoic acid is the naturally occurring enantiomer of lipoic acid, the form made in mitochondria and used as a cofactor for energy-producing enzymes.
Typical: 100–300 mg
Bitter Melon Extract
BotanicalBitter melon is a tropical vine fruit eaten as a vegetable across Asia and used traditionally for blood sugar.
Typical: 500–2,000 mg
Moringa Leaf Powder
BotanicalMoringa is the dried, milled leaf of Moringa oleifera, a fast-growing tree cultivated across South Asia and Africa.
Typical: 1–3 g
White Kidney Bean Extract
BotanicalWhite kidney bean extract is a protein fraction of Phaseolus vulgaris that inhibits alpha-amylase, the enzyme that digests starch.
Typical: 500–1,500 mg
Nettle Leaf
BotanicalNettle leaf is the dried aerial part of Urtica dioica, a nutrient-dense green used in traditional European herbalism and in modern seasonal and immune formulas.
Typical: 300–600 mg
Sulforaphane (Broccoli Seed Extract with Myrosinase)
BotanicalSulforaphane is the isothiocyanate formed when glucoraphanin from broccoli seeds or sprouts meets the enzyme myrosinase.
Typical: 100–400 mg
Chromium Polynicotinate
MineralTrivalent chromium bound to niacin (nicotinic acid), marketed as a food-like glucose-tolerance-factor form and sold under trade names such as ChromeMate.
Typical: 200–400 mcg
Cinnamon Water Extract (Cinnulin PF)
BotanicalA branded water-soluble extract of cinnamon bark concentrated for type-A polyphenol polymers and largely free of the fat-soluble coumarins and volatile oils found in whole bark.
Typical: 250–500 mg
Palatinose (Isomaltulose)
OtherIsomaltulose is a disaccharide of glucose and fructose joined by an alpha-1,6 bond, produced enzymatically from sucrose.
Typical: 15–30 g
Banaba Leaf Extract
BotanicalBanaba is a Southeast Asian tree whose leaves have been used in Philippine folk practice for blood sugar.
Typical: 16–48 mg
Benfotiamine
VitaminBenfotiamine is a synthetic, lipid-soluble derivative of thiamin that is converted to thiamin in the body.
Typical: 150–600 mg
Maitake (Grifola frondosa)
MushroomMaitake is a clustered, edible polypore whose proprietary beta-glucan extract, D-fraction, has been studied in small oncology and immunology trials, including a phase II study in myelodysplastic syndromes.
Typical: 500–2,000 mg
D-Chiro-Inositol
OtherD-chiro-inositol is a minor inositol isomer produced from myo-inositol by an insulin-dependent epimerase.
Typical: 100–600 mg
Vanadyl Sulfate
OtherA vanadium(IV) salt that was popular in 1990s bodybuilding products and remains in some blood-sugar formulas.
Typical: 10–50 mg